Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Several conformations of the Alexa 488 dye and its linker attached to the proline chain during MD simulations are seen in the simulations. For the open conformation, fast large amplitude motions are seen for the dye whereas hydrophobic interactions restrict the dye mobility in the closed conformations (one representative example is shown). Additionally slow transition between the open and closed conformations are seen.
