Table 1. Mean inhibitory concentrations (IC50) of OMP and 5-FU in various human pancreatic cancer cell lines.
cell line | OMP | PZL | 5-FU | Gemcitabine | ||||
IC | conf. int. | IC | conf. int. | IC | conf. int. | IC | conf. int. | |
MiaPaCa-2 | 42.4 | 38–45 | 68.4 | 57.8–79.7 | 0.20 | 0.12–0.27 | 0.021 | 0.013–0.028 |
ASPC-1 | 11.2 | 7.1–15.4 | 38.2 | 12.3–64.1 | 0.45 | 0.35–0.55 | 0.036 | 0.007–0.07 |
Panc-1 | 31.8 | 13.4–49.0 | 22.2 | 10.7–33.8 | 0.57 | 0.38–0.76 | 0.24 | n.n.-0.57 |
Colo357 | 26.4 | 20.0–32.8 | 69.7 | 46.6–92.8 | 0.48 | 0.36–0.60 | 0.0032 | 0.0008–0.007 |
PancTu-1 | 20.7 | 5.9–35.4 | 43.8 | 25.1–62.5 | 0.17 | 0.08–0.26 | 0.035 | n.n.-0.09 |
Panc-89 | 9.1 | 8.4–9.7 | 98.8 | 89.2–108.4 | 0.20 | 0.08–0.26 | 0.005 | 0.0005–0.01 |
The IC50 were determined by ATP-bioluminescence. All values are listed in µg/ml.
Abbreviations: conf. int. - 90% confidence intervals.