Table 2. Detection of growth-stimulatory effects of 5-FU and GEM in lower doses.

Cell line	5-FU			GEM
	c (µg/ml)	fu	p (t-test)	c (µg/ml)	fu	p (t-test)
ASPC-1	0.5	1.4	0.047	0.02	0.5	0.002
	1	0.9	0.38	0.04	0.4	0.007
MiaPaCa-2	0.125	0.9	0.4	0.01	0.36	0.01
	0.25	0.8	0.2	0.02	0.15	0.003
Colo357	0.5	0.3	0.02	0.02	0.9	0.2
	1	0.2	0.01	0.04	0.8	0.06
Panc-1	0.5	1.3	0.02	0.01	0.5	0.0001
	1	1.6	0.0003	0.02	0.4	<0.0001
Panc-89	0.125	0.2	0.01	0.002	0.7	0.02
	0.25	0.9	0.3	0.004	0.6	0.04
PancTu-1	0.125	2.2	0.005	0.02	0.35	0.01
	0.25	2.2	0.0001	0.04	0.3	0.01

Significant elevations of cell counts compared to the control groups could be observed upon 5-FU in ASPC-1 (at 0.5 µg/ml 5-FU), Panc-1 (at 0.5 and 1 µg/ml 5-FU) and PancTu-1 (at 0.125 and 0.25 µg/ml) cells. In contrast, no hormesis could be observed upon GEM.

Abbreviations: c-concentration, fu-unaffected fraction (cell count related to control).