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. 2011 May 24;6(5):e20364. doi: 10.1371/journal.pone.0020364

Figure 1. Conditional knockout of Grp94 in the bone marrow.

Figure 1

A) Schematic drawings of the Grp94 wild-type (WT) allele, the floxed allele and the knockout (KO) allele. The exons are boxed and numbered. The loxP sites (closed triangle) and the FRT site (open triangle) and expected PCR products for genotyping is indicated. B) Representative BM PCR genotyping results of mice with indicated genotypes after pI.pC injection. C) Grp94 mRNA expression measured by quantitative real-time PCR from WT (n = 16) and cKO (n = 18) mouse BM after pI.pC injection. The level of Grp94 mRNA was normalized against the level of internal control 18S RNA. The data are presented as mean ± s.e., ***p<0.001.