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. Author manuscript; available in PMC: 2012 Jun 30.
Published in final edited form as: Neuroscience. 2011 Apr 20;185:50–60. doi: 10.1016/j.neuroscience.2011.04.032

Figure 3. Open field and elevated plus maze activity do not indicate anxiogenic or locomotor effects of IGF-1 deficiency.

Figure 3

A: Time spent in the central area of a novel open field was recorded as a measure of anxiety. No treatment significantly altered this measure. B: Total distance traveled in the open field demonstrated no differences in basal locomotion between groups. n(Liver EGFP, Brain EGFP)=11, n(Liver EGFP, Brain Cre)=8, n(Liver Cre, Brain EGFP)=8, n(Liver Cre, Brain Cre)=11. C: As a second measure of anxiety, time spent in the open arms of an elevated plus maze was examined. Two-way ANOVA revealed no main effect of viral vectors. D: Animals administered Cre-expressing vectors to CA1 have a marginally higher activity level as analyzed by Two-way ANOVA, but no significant differences were found between any pair of treatment groups, nor does such a trend appear in open field data. n(Liver EGFP, Brain EGFP)=11, n(Liver EGFP, Brain Cre)=5, n(Liver Cre, Brain EGFP)=8, n(Liver Cre, Brain Cre)=11. ‡Main effect of brain vector, p=0.024. Data represent mean ± SEM.