Table 1.
Comparison of the physical properties of free PpIX and PpIX/PEG-PLA micelles.
| PpIX samples | PpIX loading (wt%)a |
Diameter (nm)b |
ξ (mV) |
Soret band (nm) |
Q-bands (nm) |
Emission (nm) |
ΦΔc |
|---|---|---|---|---|---|---|---|
| Free PpIXd | – | – | – | 352, 450 | 535, 562, 589, 642 | 620 | 0.05 |
| PEG-PLA micelles | – | 31±5 | -6.9±1.5 | – | – | – | – |
| PpIX-encapsulated | 0.2 % | 30±6 | -13.3±1.7 | 404 | 506, 538, 574, 629 | 630 | 0.82 |
| micelles | 4% | 33±6 | -19.6±1.3 | 348, 472 | 542, 565, 593, 640 | 630 | 0.06 |
| PpIX-conjugated | 0.2% | 30±6 | -7.4±1.1 | 403 | 506, 538, 575, 630 | 630 | 1.0 |
| micelles | 4% | 32±6 | -20.8±1.6 | 385 | 510, 542, 581, 635 | 632, 672 | 0.48 |
a
PpIX loading density was measured as the weight of PpIX over that of total micelles.
b
By dynamic light scattering.
c
Relative 1O2 yields that were normalized to that of 0.2% PpIX-conjugated micelles.
d
PpIX at 2 μM in phosphate buffer (PB) at pH 7 (aggregated state).