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. Author manuscript; available in PMC: 2012 Jun 1.

Published in final edited form as: J Oral Maxillofac Surg. 2011 Apr 5;69(6):e50–e57. doi: 10.1016/j.joms.2010.12.049

Microsphere and scaffold fabrication process. (A) Microspheres were made from a polymer stream (20% w/v PLGA in DCM) and annular carrier stream (0.5% w/v PVA in DI H₂O) with an ultrasonic transducer; (B) Programmable pumps created a gradient in microsphere types; (C) Experimental groups for each time point (six rabbits at twelve weeks). Sham surgeries were performed with no implant, blank groups contained microspheres with no growth factor, gradient groups contained a gradient of BMP-2 and TGF-β₁; (D) Microscope image of microsphere-based scaffold with particles of 70 μm. Scale bar = 500 μm.

Microsphere and scaffold fabrication process. (A) Microspheres were made from a polymer stream (20% w/v PLGA in DCM) and annular carrier stream (0.5% w/v PVA in DI H₂O) with an ultrasonic transducer; (B) Programmable pumps created a gradient in microsphere types; (C) Experimental groups for each time point (six rabbits at twelve weeks). Sham surgeries were performed with no implant, blank groups contained microspheres with no growth factor, gradient groups contained a gradient of BMP-2 and TGF-β₁; (D) Microscope image of microsphere-based scaffold with particles of 70 μm. Scale bar = 500 μm.