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. Author manuscript; available in PMC: 2012 May 31.
Published in final edited form as: Biochemistry. 2011 May 3;50(21):4786–4795. doi: 10.1021/bi200033z

Figure 3.

Figure 3

Thermochemical data for interactions of inhibitors with PRL76V. A. DSC thermograms of PRL76V in the presence and absence of inhibitors in 50 mM sodium acetate buffer, pH 5.0. The thermal transition temperatures (curve maxima) are in parentheses. Inhibitors were in a twofold molar excess relative to dimeric PRL76V. B. ITC trace of 5 μM PRL76V titrated with 80 μM RPB (KL = 61 nM) in 50 mM sodium acetate buffer, pH 5. C. Displacement of RPB (total concentration of 16 μM) bound to 4.2 μM PRL76V by titration with DRV (50 μM; KL for DRV = 0.79 nM).