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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: J Intern Med. 2011 Jun;269(6):604–613. doi: 10.1111/j.1365-2796.2011.02376.x

Table I.

Overview over non-dietary therapies for coeliac disease

Mode of action Compound Compound
class		 Company/
university		 Status
Topical steroid Budesonide Small molecule Generic drug Approved
Rho kinase inhibition Fasudil Small molecule Generic drug Approved
Glutenase ALV003 Enzyme Alvine, USA Phase II
Glutenase AN-PEP Enzyme DSM, Netherlands Phase I + II
Glutenase STAN1 (enzyme supplements) Enzyme Heim Pal Childrens Hospital, Hungary Phase I + II
Zonulin antagonist AT-1001 Peptide Alba, USA Phase II
CCR9 antagonist CCX282-B Small molecule ChemoCentryx, USA Phase II
Immune modulation Necator americanus Parasite Princess Alexandra Hospital, Australia Phase II
Peptide vaccination Nexvax2 Peptide Nexpep, Australia Phase I
Anti-IL-15 AMG 714 Monoclonal antibody Amgen, USA Phase II in RA1, psoriasis
Anti-IFN-γ Fontolizumab Monoclonal antibody PDL and Biogen Idec, USA Phase II in IBD1, (discont.)
Anti-CD3 Visilizumab Monoclonal antibody Facet, USA Phase II in UC1,, GvHD1,
Anti-CD3 Teplizumab Monoclonal antibody MacroGenics, USA Phase II in T1D1,
Anti-CD3 Otelixizumab Monoclonal antibody Tolerx, USA Phase III in T1D1,
Anti-CD20 Rituximab Monoclonal antibody Biogen Idec, USA Approved
Anti-CD20 Tositumab Monoclonal antibody GlaxoSmithKline, USA Approved
Anti-CD20 Ibritumomab Monoclonal antibody Spectrum, USA Approved
RhoA inhibition BA-210 Recombinant protein Alseres, USA Phase II in spinal cord injury
TG2 inhibitor Dihydroisoxazoles Small molecule Stanford University, USA Discovery
TG2 inhibitor ZED-101 Small molecule Zedira, Germany Discovery
TG2 inhibitor Cinnamoyl triazoles Small molecule University of Montreal, Canada Discovery
HLA-DQ2 blocker Dimeric analogue of gluten peptide Peptide Stanford University, USA & University of Oslo, Norway Discovery
HLA-DQ2 blocker Azidoproline analogue of gluten peptide Peptide Leiden University, Netherlands Discovery
Gluten tolerisation Genetically modified Lactococus lactis Bacteria ActoGeniX, Belgium Discovery
Gluten-sequestering polymers P(HEMA-co-SS) Polymer resin University of Montreal, Canada Discovery
1

RA: Rheumatoid arthritis; IBD: inflammatory bowel disease; UC: ulcerative colitis; GvHD: graft versus host disease; T1D: type 1 diabetes,