Table 1.
MICs of PME-1-producing P. aeruginosa and its transformant and the E. coli clone
| Antimicrobial | MIC (μg/ml) |
||||
|---|---|---|---|---|---|
|
P. aeruginosa |
E. coli |
||||
| GB771 | PAO1 (pGB771)a | PAO1 | DH10B (pPME-1)b | DH10B [pBC-SK(−)] | |
| Ampicillin | >256 | >256 | >256 | >256 | 2 |
| Cefoxitin | >256 | >256 | >256 | 4 | 2 |
| Ticarcillin | >256 | 256 | 32 | >256 | 2 |
| Aztreonam | >256 | 16 | 4 | >256 | 0.125 |
| Ceftazidime | 64 | 64 | 2 | 256 | 0.125 |
| Ceftazidime-clavulanic acid | 16 | 32 | 2 | 0.25 | 0.125 |
| Cefotaxime | >256 | >256 | 16 | 4 | 0.063 |
| Cefotaxime-clavulanic acid | >256 | >256 | 16 | 0.032 | 0.032 |
| Cefepime | 64 | 8 | 1 | 2 | 0.063 |
| Imipenem | 32 | 1 | 1 | 0.25 | 0.125 |
| Meropenem | 32 | 0.5 | 0.5 | 0.063 | 0.016 |
| Doripenem | 16 | 1 | 0.5 | 0.032 | 0.016 |
a
Transformant harboring a PME-1-encoding plasmid from P. aeruginosa GB771.
b
Transformant harboring a PCR-generated recombinant plasmid encoding PME-1.