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Kinetic parameters of PME-1
| Substrate | Km (μM)a | kcat (s−1) | kcat/Km (μM−1 · s−1) |
|---|---|---|---|
| Ampicillin | 3.2 ± 1.3 | 8.1 ± 0.04 | 2.5 |
| Ticarcillin | 7.2 ± 0.8 | 8.6 ± 0.04 | 1.2 |
| Cephalothin | 16.7 ± 4.6 | 110.1 ± 3.9 | 6.6 |
| Ceftazidime | 61.8 ± 2.4 | 13.7 ± 0.2 | 0.22 |
| Cefotaxime | 31.4 ± 2.8 | 23.7 ± 3.5 | 0.75 |
| Aztreonam | 8.7 ± 0.4 | 34.6 ± 0.1 | 4.0 |
Km values are the means ± standard deviations from three different measurements.
