Table 1.
Paradoxical growth of Candida albicans mutant strains
| Straina | Description | Caspofungin MIC (μg/ml) | Occurrence of paradoxical growthb | Reference |
|---|---|---|---|---|
| SC5314 | Wild type | 0.125 | Yes (2-8) | 13 |
| CAI-12 | URA3/ura3Δ | 0.25 | Yes (1-4) | 11 |
| irs4 mutant 1* | URA3/ura3Δ irs4Δ::hisG/irs4Δ::hisG | 0.25 | No | 1 |
| irs4 mutant 2† | irs4Δ/irs4Δ | 0.25 | No | 2 |
| inp51 mutant† | inp51Δ/inp51Δ | 0.25 | No | 2 |
| efg1 mutant* | ura3Δ/ura3Δ efg1Δ::hisG/efg1Δ::hisG-URA3-hisG | 0.25 | Yes (1-4) | 16 |
| efg1/cph1 mutant* | ura3Δ/ura3Δ cph1Δ::hisG/cph1Δ::hisG efg1Δ::hisG/efg1Δ::hisG-URA3-hisG | 0.25 | Yes (1-4) | 16 |
a
*, Mutants created by using the Ura-Blaster method (the comparator strain is C. albicans CAI-12); †, mutants created by using the SAT-flipper method (the comparator strain is C. albicans SC5314).
b
If yes, the range (in μg/ml) is indicated in parentheses. The range was defined by the lowest and highest concentrations associated with a paradoxical effect for a given isolate.