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Effect of PSI-352938 and its potential cyclic metabolites on PKG activity. (A) Chemical structures of cyclic cGMP, PSI-352938, PSI-354091, and PSI-354519; (B) effect of PSI-352938, PSI-354091, and PSI-354519 on the activation of PKG compared to that of cGMP; (C) effect of PSI-352938, PSI-354091, and PSI-354519 on the cGMP-mediated PKG activation compared to that of the no-compound control.
