Fig. 2.

Rebound and clearance study of HCV replicon RNA. Replicon cells were treated with PSI-352938, PSI-7851, a benzothiadiazine NNI, or ITMN-191 for 2 weeks in the absence of G418, followed by removal of compounds and G418 selection for an additional 2 weeks. An aliquot of cells at each passage was harvested for RNA analysis. Level of HCV replicon RNA change in the presence of DMSO (■), PSI-352938 (●), PSI-7851 (▲), a benzothiadiazine NNI (♦) or ITMN-191 (×) at their approximate 1× EC₅₀s (A), 10× EC₅₀s (B), or 20× EC₅₀s (C).