Table 2.
Nonsusceptibility of S. pneumoniae isolates from patients with pneumonia and with AECOPD
| Antibiotic | No. (%) of nonsusceptible isolates from patients with pneumonia |
P valuea | Total no. (%) of nonsusceptible isolates |
P valueb | ||
|---|---|---|---|---|---|---|
| COPD (n = 171) | Non-COPD (n = 230) | Patients with pneumonia (n = 401) | Patients with AECOPD (n = 398) | |||
| Oral benzylpenicillin | 19 (11.1) | 35 (15.2) | 0.3 | 54 (13.5) | 81 (20.4) | 0.01 |
| Parenteral penicillin | 0 (0) | 0 (0) | 0 (0) | 4 (1) | 0.061 | |
| Amoxicillin | 3 (1.8) | 5 (2.2) | 1 | 8 (2) | 10 (2.5) | 0.64 |
| Cefotaxime | 2 (1.2) | 2 (0.9) | 1 | 4 (1) | 9 (2.3) | 0.17 |
| Ertapenemc | 0 (0) | 0 (0) | 0 (0) | NDd | ||
| Erythromycin | 24 (14) | 26 (11.3) | 0.4 | 50 (12.5) | 79 (19.8) | 0.005 |
| Azithromycin | 24 (14) | 26 (11.3) | 0.4 | 50 (12.5) | 79 (19.8) | 0.005 |
| Quinupristin-dalfopristin | 0 (0) | 1 (0.4) | 1 (0.2) | 1 (0.3) | ||
| Clindamycin | 16 (9.4) | 16 (7) | 0.5 | 32 (8) | 63 (15.8) | <0.001 |
| Tetracycline | 17 (9.9) | 20 (8.7) | 0.6 | 37 (9.2) | 71 (17.8) | <0.001 |
| Trimethoprim-sulfamethoxazole | 29 (17) | 39 (17) | 1 | 68 (17) | 79 (19.8) | 0.18 |
| Chloramphenicol | 2 (1.2) | 1 (0.4) | 3 (0.7) | 10 (2.5) | 0.055 | |
| Rifampin | 0 (0) | 1 (0.4) | 1 (0.2) | 0 (0) | ||
| Ciprofloxacin | 13 (7.6) | 14 (6.1) | 0.7 | 27 (6.7) | 38 (9.5) | 0.15 |
| Levofloxacin | 3 (1.8) | 0 (0) | 3 (0.7) | 16 (4.0) | 0.002 | |
a
P values between patients with pneumonia and with and without COPD as an underlying disease.
b
P values between all patients with pneumonia and patients with acute exacerbation of COPD.
c
Ertapenem susceptibility was determined by Etest.
d
ND, not determined.