Table 4.
ACH-702 antibacterial activity against anaerobic clinical isolates
| Organism (no. of isolates) | Antimicrobial | MIC (μg/ml)a |
||
|---|---|---|---|---|
| Range | MIC50 | MIC90 | ||
| Bacteroides fragilis (10) | ACH-702 | 0.06–0.12 | 0.12 | 0.12 |
| Clindamycin | 0.25–4 | 1 | 4 | |
| Imipenem | 0.25–0.5 | 0.25 | 0.25 | |
| Penicillin | 0.5–32 | 16 | 16 | |
| Clostridium difficile (10) | ACH-702 | 0.25–4 | 0.25 | 4 |
| Clindamycin | 1–>32 | 2 | >32 | |
| Imipenem | 4–16 | 4 | 4 | |
| Penicillin | 0.5–4 | 1 | 1 | |
| Propionibacterium acnes (10) | ACH-702 | 0.03–0.06 | 0.06 | 0.06 |
| Clindamycin | ≤0.03–0.06 | 0.06 | 0.06 | |
| Imipenem | 0.03–0.12 | 0.06 | 0.06 | |
| Penicillin | ≤0.12–≤0.12 | ≤0.12 | ≤0.12 | |
| Peptostreptococcus sp. (10) | ACH-702 | 0.008–0.12 | 0.015 | 0.06 |
| Clindamycin | 0.12–4 | 0.25 | 1 | |
| Imipenem | 0.03–0.5 | 0.06 | 0.25 | |
| Penicillin | ≤0.25–0.5 | 0.25 | 0.5 | |
a
For current CLSI breakpoints for comparators, see reference 14.