Table 4.
Lopinavir pharmacokinetic parameters derived from simulations of different lopinavir-ritonavir doses compared with the standard dosea
| Parameter | GMR (95% CI) for regimen: |
||
|---|---|---|---|
| B/A | C/A | D/A | |
| AUC0–12 | 0.349 (0.349–0.350) | 0.616 (0.616–0.617) | 1.418 (1.415–1.420) |
| Cmax | 0.375 (0.373–0.378) | 0.597 (0.595–0.598) | 1.352 (1.344–1.355) |
| Ctrough | 0.270 (0.266–0.272) | 0.688 (0.685–0.692) | 1.685 (1.671–1.700) |
a
Lopinavir pharmacokinetic parameters were derived from simulations of different lopinavir-ritonavir doses (200 mg-50 mg, 200 mg-150 mg, and 400 mg-200 mg twice daily) in comparison with the standard dose of 400 mg-100 mg twice daily. Regimen A, 400 mg-100 mg; regimen B, 200 mg-50 mg; regimen C, 200 mg-150 mg; regimen D, 400 mg-200 mg. AUC0–12, area under the concentration-time curve at 0 to 12 h postdose; Cmax, maximum concentration; Ctrough, trough concentration, i.e., concentration at 12 h postdose; GMR, geometric mean ratio; CI, confidence interval.