Table 5.
Estimated proportion of variance (with 95% confidence intervals) of susceptibility to lower urinary tract infections in women explained by genetic, shared environmental, and nonshared environmental factors
| Genetic effects (95% CI)1 |
Shared environment (95% CI)1 |
Nonshared environment (95% CI)1 |
||||
|---|---|---|---|---|---|---|
| Micturition frequency (ICS) | 0.40 | (0.31–0.48) | * | – | 0.60 | (0.52–0.69) |
| ≥8 micturitions/24 h | 0.40 | (0.32–0.47) | * | – | 0.60 | (0.53–0.68) |
| Nocturia (ICS) | 0.48 | (0.41–0.54) | * | – | 0.52 | (0.46–0.49) |
| Nocturia ≥2 micturitions/night |
0.34 | (0.06–0.54) | 0.12 | (0–0.37) | 0.53 | (0.46–0.62) |
| Overactive bladder without incontinence = OAB dry |
0.04 | (0–0.46) | 0.31 | (0–0.45) | 0.65 | (0.52–0.77) |
| Overactive bladder with incontinence = OAB wet |
– | – | 0.43 | (0.23–0.61) | 0.57 | (0.39–0.77) |
| All overactive bladder | 0.10 | (0–0.46) | 0.25 | (0–0.43) | 0.65 | (0.53–0.76) |
| Stress urinary incontinence | 0.34 | (0–0.66) | 0.20 | (0–0.54) | 0.47 | (0.34–0.62) |
| Urge urinary incontinence | 0.37 | (0–0.65) | 0.10 | (0–0.52) | 0.53 | (0.35–0.75) |
| Mixed urinary incontinence | 0.18 | (0–0.66) | 0.27 | (0–0.58) | 0.55 | (0.34–0.78) |
| All urinary incontinence | 0.51 | (0.07–0.67) | 0.04 | (0–0.42) | 0.45 | (0.33–0.58) |
CI = confidence interval; ICS = International Continence Society; OAB = overactive bladder.
Indicates that the pattern of correlations in monozygotic (MZ) and dizygotic (DZ) pairs with MZ correlations more than two times larger than DZ correlations was incompatible with estimating shared environmental influences (concerns frequency and nocturia only). For OAB wet, the correlation pattern suggests a model with only environmental components (shared and nonshared).
Confidence intervals, including zero, indicate a statistically nonsignificant contribution of the factor.