Table 4.
Literature data about NO and oxidative stress-related genes and proteins that have been altered during obstructive nephropathy. We have reported here only molecules of which activity or expression has been significantly modified compared to healthy control (human), sham-animals (animal model) or control cells (in vitro).
| Animal model | In vitro | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene symbol | Gene name | Human | Ref. | CUUO | Ref. | Stretch | Shear stress | Pressure | Ref. |
| Cat | Catalase | Down | Ricardo et al. (1997) | ||||||
| Nos2 | iNOS; nitric oxide synthase 2, inducible | Up* (t) | Valleset al. (2003) | Up (5d) Down (2w) | Manucha andValles (2008) | Up*/ =* | Up* | Miyajima et al. (2000a), Hegarty et al. (2002), Broadbelt et al. (2007) | |
| Nos3 | eNOS; nitric oxide synthase, inducible | Up* (t) | Valleset al. (2003), Valleset al. (2007) | Down (2w) | Silversteinet al. (2003a) | ||||
| Nox1 | NADPH oxidase | Down* (5d) Up* (2w) | Manucha andValles (2008) | ||||||
| Sod1 | SOD; superoxide dismutase | Down* (2w) | Manucha andValles (2008) | ||||||
u: urine; t: tissue; p: plasma; w: weeks of obstruction; d: days of obstruction; CUUO: complete UUO; *activity; Ref.: references.