Table 6.
Literature data about renin–angiotensin system (and associated)-related genes and proteins that have been altered during obstructive nephropathy. We have reported here only molecules of which activity or expression has been significantly modified compared to healthy control (human), sham-animals (animal model) or control cells (in vitro)
| Animal model | In vitro | ||||||
|---|---|---|---|---|---|---|---|
| Gene symbol | Gene name | Human | Ref. | CUUO | Ref. | Stretch | Ref. |
| Agtr1 | Angiotensin II receptor, type 1 | = (t) | Murer et al. (2006), Valles et al. (2007) | Down (1d) Up (4w) | Yoo et al. (1997) | Up | Durvasula et al. (2004),Kolb et al. (2004) |
| Agtr2 | Angiotensin II receptor, type 2 | = (t) | Murer et al. (2006), Valles et al. (2007) | Down(1d; 4w) | Yoo et al. (1997) | = | Durvasula et al. (2004) |
| Bdkrb2 | Bradykinin receptor B2 | Up (4w) | Chen et al. (2007) | ||||
| Gja4 | Connexin 37 | Up (2w) | Silverstein et al. (2003b) | ||||
| Gja5 | Connexin 40 | Up (2w) | Silverstein et al. (2003b) | ||||
| Pcsk1n | proSAAS;proprotein convertase1 inhibitor | Down(u) | Decrameret al. (2006) | ||||
| Ren | Renin | Up*(p) | Bajpaiet al. (2007) | Up(2w, 4w) | el-Dahr et al. (1991), Chevalier et al. (1996), Chung and Chevalier (1996), Yoo et al. (1997), Silverstein et al. (2003a) | Up | Ricardo et al. (2000) |
u: urine; t: tissue; p: plasma; w: weeks of obstruction; d: days of obstruction; CUUO: complete UUO; *activity; Ref.: references.