Table 7.
Animal model | In vitro | ||||||||
---|---|---|---|---|---|---|---|---|---|
Gene symbol | Gene name | Human | Ref. | PUUO | CUUO | Ref. | Stretch | Pressure | Ref. |
Egf | Epidermal growth factor | = / Down(u, t) | Grandaliano et al. (2000), Yang et al. (2006), Taha et al. (2007a) | Down (2w, 4w) | Chung and Chevalier (1996) | ||||
Egfr | Epidermal growth factor receptor; Erbb1 | Up (5d to 4w) | Nguyen et al. (1999a) | Up* | (Broadbelt et al. (2009) | ||||
Tgfa | TGFα; transforming growth factor α | Up (5d to 4w) | Nguyen et al. (1999a) | ||||||
Vegfa | Vascular endothelial growth factor A | Up/Down (2w, 4w) | Down (2w, 4w) | Burt et al. (2007), Fenghua et al. (2009) | |||||
Edn1 | Endothelin 1 | Up (u) | Taha et al. (2007a) | ||||||
Spp1 | Osteopontin; secreted phosphoprotein 1 | Up | Diamond et al. (1998), Endlich et al. (2002) |
u: urine; t: tissue; p: plasma; w: weeks of obstruction; d: days of obstruction; CUUO: complete UUO; *activity; Ref.: references.