Table 7.
Literature data about cytokine and growth factor-related genes and proteins that have been altered during obstructive nephropathy. We have reported here only molecules of which activity or expression has been significantly modified compared to healthy control (human), sham-animals (animal model) or control cells (in vitro)
| Animal model | In vitro | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene symbol | Gene name | Human | Ref. | PUUO | CUUO | Ref. | Stretch | Pressure | Ref. |
| Egf | Epidermal growth factor | = / Down(u, t) | Grandaliano et al. (2000), Yang et al. (2006), Taha et al. (2007a) | Down (2w, 4w) | Chung and Chevalier (1996) | ||||
| Egfr | Epidermal growth factor receptor; Erbb1 | Up (5d to 4w) | Nguyen et al. (1999a) | Up* | (Broadbelt et al. (2009) | ||||
| Tgfa | TGFα; transforming growth factor α | Up (5d to 4w) | Nguyen et al. (1999a) | ||||||
| Vegfa | Vascular endothelial growth factor A | Up/Down (2w, 4w) | Down (2w, 4w) | Burt et al. (2007), Fenghua et al. (2009) | |||||
| Edn1 | Endothelin 1 | Up (u) | Taha et al. (2007a) | ||||||
| Spp1 | Osteopontin; secreted phosphoprotein 1 | Up | Diamond et al. (1998), Endlich et al. (2002) | ||||||
u: urine; t: tissue; p: plasma; w: weeks of obstruction; d: days of obstruction; CUUO: complete UUO; *activity; Ref.: references.