Table 1.
Summary of the history of susceptibility to experimental autoimmune glomerulonephritis (EAG) in the rat
| Strain | Immunogen | Severity of EAG |
|---|---|---|
| WKY | Bovine GBM | +++ |
| SHR | Bovine GBM | +++ |
| F344 | Bovine GBM | +/− |
| LEW | Bovine GBM | +/− |
| BN | Rat GBM | ++ |
| PVG | Rat GBM | + |
| DA | Rat GBM | + |
| LEW | Rat GBM | − |
| WAG | Rat GBM | − |
| WKY (RT1-l) | Rat GBM | +++ |
| WKY (RT1-k) | Rat GBM | ++ |
| WKY | Human α3(IV)NC1 | +++ |
| WKY | Rat α3(IV)NC1 | +++ |
| LEW | Rat α3(IV)NC1 | − |
| WKY | Human pCol(28–51) | ++ |
| WKY | Rat pCol(28–40) | +++ |
| WKY | Rat pCol(24–38) | +++ |
α3(IV)NC1, the non-collagenous domain of the alpha 3 chain of type IV collagen; GBM, glomerular basement membrane; pCol(24–38), a 15-mer immunodominant peptide from the N-terminus of rat α3(IV)NC1.