Fig. 3.

Least square mean (LSM) changes versus baseline in msSBP (a) and msDBP (b) at the 8-week endpoint. ∗ p < 0.0001, ∗∗ p < 0.05, vs. ramipril. c Summary statistics for msSBP and msDBP throughout the double-blind period (ITT population). n is the number of ITT patients with both baseline and endpoint non-missing values (last-observation-carried-forward approach). Error bars denote SEM (from an analysis of covariance with baseline msSBP as a covariate and treatment at baseline as factors in the model).