TABLE 4.
Summary of plasma APV pharmacokinetics
| Parameter | Median (interquartile range)
|
||
|---|---|---|---|
| 908 1,395 mg BIDa | 908 1,860 mg BIDb | APV 1,200 mg BIDc | |
| Single dose | |||
| AUC0-∞ (h · μg/ml) | 20.3 (16.4-27.4) | 45.6 (38.1-52.5) | 23.3 (17.4-32.6) |
| Cmax (μg/ml) | 5.29 (3.29-7.42) | 8.61 (6.94-10.66) | 7.37 (5.29-8.46) |
| tmax (h) | 2.5 (1.5-3.0) | 1.9 (1.3-2.5) | 1.3 (1.0-1.8) |
| t1/2 (h) | 6.4 (5.6-11.2) | 7.2 (5.0-9.8) | 6.8 (6.5-12.9) |
| Steady state | |||
| AUCτ,ss (h · μg/mL) | 16.5 (12.6-21.3) | 16.9 (13.9-21.9) | 16.5 (12.0-21.4) |
| Cmax,ss (μg/ml) | 4.67 (3.92-6.52) | 4.82 (3.71-5.8) | 7.01 (4.67-9.27) |
| Cτ,ss (μg/ml) | 0.305 (0.249-0.539) | 0.340 (0.189-0.502) | 0.246 (0.186-0.365) |
| tmax,ss (h) | 1.2 (1.0-2.0) | 1.5 (0.8-2.5) | 1.0 (0.8-1.0) |
a
n = 15 for single-dose values; n = 22 for steady-state values.
b
n = 18 for single-dose values, except for Cmax and t1/2, for which n was 22; n = 31 for steady-state values.
c
n = 16 for single-dose values; n = 53 for steady-state values.