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Relationships between PK and PD parameters and number of organisms remaining in the thighs of neutropenic mice after 24 h of therapy with multiple dosing regimens of daptomycin. (a) The PK and PD parameters are the time that the concentration remains above the MIC for total and free drug; (b) the PK and PD parameters peak/MIC and 24-h AUC/MIC ratios for total drug. The dotted lines represent the log10 CFU per thigh at the start of therapy.
