TABLE 3.

MICs, static doses, and magnitudes of 24-h AUC/MIC and peak/MIC ratios required to produce a bacteriostatic effect and killing of 1 and 2 log₁₀ CFU per thigh over 24 h

Organism	MIC (mg/liter)	Static dose (mg/kg/24 h)a	24-h AUC/MIC ratio			Peak/MIC ratio
			Static dose	1 log killing	2 log killing	Static dose	1 log killing	2 log killing
S. pneumoniae ATCC 10813	0.12	2.16	168	390	582	25.1	48.2	86.5
S. pneumoniae CDC 145	0.12	0.954	74.7	108	157	11.8	16	23.4
S. pneumoniae CDC 1199	0.12	2.62	203	346	594	30.5	51.5	88.1
S. pneumoniae CDC 1396	0.12	1.5	117	150	190	17.4	22.3	28.3
S. pneumoniae CDC 673	0.12	3.05	237	467	815	35.5	69.5	121
S. pneumoniae CDC 1325	0.25	5.34	199	373	673	29.8	55.5	100
S. pneumoniae CDC 49619	0.25	4.9	182	337	703	27.3	50	104
S. pneumoniae CDC 1020	0.25	3.39	126	215	395	18.9	32	58.5
Mean ± SD (95% CI) for S. pneumoniae			160 ± 51 (72-316)	290 ± 121 (100-660)	498 ± 131 (117-813)	24 ± 7.6 (11-44)	42.1 ± 17.2 (15-98)	73.9 ± 34.2 (20-204)
S. aureus ATCC 25923	0.5	20.8	388	594	896	59	109	197
S. aureus ATCC 33591	0.5	28.6	537	733	1,099	93.6	147	264
S. aureus ATCC 29213	0.5	22.5	420	588	788	66.2	107	163
S. aureus ATCC 6538p	0.5	21.9	409	750	1,460	63.6	152	398
Mean ± SD (95% CI) for S. aureus			438 ± 67 (316-550)	666 ± 87 (501-832)	1,061 ± 296 (603-1,738)	70.6 ± 15.6 (47-102)	129 ± 24.1 (86-184)	255 ± 104 (114-507)
E. faecium VA 20	2	0.203	0.94	4.14	NDb	0.14	0.62	ND
E. faecium VA 21	2	0.36	1.67	33.8	ND	0.25	5.05	ND

^aCalculations are based on total drug levels. Values for free drug are 10% of these values.

^bND, not determined.