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. 2010 Sep 20;190(6):1023–1037. doi: 10.1083/jcb.201003122

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© 2010 Winslow et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — Cumulative molecular effects of α-synuclein overexpression. Diagram illustrating the pleiotropic effects of increased intracellular levels of α-synuclein on vital intracellular pathways. The effects of α-synuclein on macroautophagy would likely cause increased susceptibility to proapoptotic insults, mitochondrial dysfunction, and increased aggregation, which are all features of PD.