Figure 4.

Effects of Rho kinase inhibition on astrocytic morphology and uptake of [³H]-d-aspartate mouse astrocytes. Treatment for 24 h with Fasudil (100 µM) or Y27632 (30 µM) produced similar changes in the pattern of GFAP expression. Scale bar = 50 µm. Both treatments significantly increased specific [³H]-d-aspartate uptake: one-way anova revealed a significant effect of treatment F[2,21] = 45.66, P < 0.01. *Significantly different from control, P < 0.05, Dunnett's multiple comparison post hoc test. Data represent mean ± SEM (n = 3–6).