Table 2.

Risk for INVEST primary outcome and rs2383207 and rs10757278

		Caucasians (n = 2364)					African Americans (n = 736)					Hispanics (n = 2770)
		Event/N, %	Unadjusted HR	p value	Adjusted HR†	p value	Event/N, %	Unadjusted HR	p value	Adjusted HR†	p value	Event/N, %	Unadjusted HR	p value	Adjusted HR†	p value
rs2383207	AA	48/444, 10.8%	0.74(0.59–0.92)	0.0058	0.75(0.60–0.93)	0.0083	2/13, 15.4%	0.74(0.41–1.31)	0.3	0.69(0.38–1.25)	0.22	9/269, 3.4%	0.92(0.65–1.30)	0.63	1.02(0.71–1.46)	0.91
(risk allele: G)	AG	79/1170, 3.8%					9/153, 5.9%					31/1182, 2.6%
	GG	41/693, 5.9%					31/549, 5.7%					32/1266, 2.5%
rs10757278	AA	56/588, 9.5%	0.80(0.65–0.98)	0.036	0.81(0.66–1.0)	0.05	21/461, 4.6%	1.85(1.19–2.86)	0.006	1.95(1.25–3.02)	0.003	23,787, 2.9%	0.94(0.69–1.30)	0.71	0.96(0.69–1.33)	0.8
(risk allele: G)	AG	81/1142, 7.1%					13/214, 6.1%					34/1320, 2.6%
	GG	36/567, 6.4%					7/43, 16.3%					16/614, 2.6%

^†hazard ratio per risk allele (A for both SNPs), adjusted for age, gender, treatment strategy, diabetes, history of myocardial infarction, heart failure, average on-treatment blood pressure, smoking and hyperlipidemia.