Table 2.
Comparison of Transgenic Mice Expressing Cre in the RPE
| Strain |
|||||
|---|---|---|---|---|---|
| Dct7 | Trp-16 | Tet-on VMD2-cre9 | Mct3-creER8 | BEST1-cre | |
| Onset of expression | E12.5 | E10.5 | 5 days after induction | 1 week after induction | P10 |
| Restricted to RPE in ocular tissue | Yes | No | Yes | Yes | Yes |
| Requires induction | No | No | Yes | Yes | No |
| Age to which function/structure is normal | Not reported | Not reported | ERG and structure, 10 mo after induction | Structure, 6 mo after induction | ERG, 12 mo; structure, 24 mo |
| % RPE Cre positive | Not reported | Not reported | Not reported; greatest activity occurs with induction at P4 | 20% when induced at P0; 5% when induced at 6 wk | 50%–90% depending on strain |