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. 2011 Mar 25;52(3):1684–1692. doi: 10.1167/iovs.10-6397

Figure 1.

Figure 1.

Effect of Hep II domain on differentiated and proliferating HTM cells. (A) Schematic of fibronectin showing the cell binding domain (CBD) and the Hep II domain. (B–E) Cell spreading in differentiated A7–1 HTM cells plated on the CBD occurs in the absence (B, D) or presence (C, E) of 472 nM of the Hep II domain of fibronectin. (F, G) In contrast, cell spreading in proliferating A7–1 HTM cells requires the addition of the Hep II domain. Cells were labeled with phalloidin (B, C, F, G) to visualize F-actin or vinculin (D, E) to visualize focal contacts and adhesions. Bar, 20 μm.