Table 2.

Voronoi Analysis Results

	Eccentricity (°)	Average Area (arcmin2)	Area SD (%)	Six-Sided Polygons (%)	Sides SD (n)
Healthy 1	0.95 ST	0.78	10.3	57	11.6
	1.1 N	0.73	10.1	79	8.2
	1.52 N	0.92	12.2	64	10
	1.6 I	1.18	8.7	55	12.2
	2.75 IT	1.7	13.2	50	13.5
Healthy 2	0.67 IT	0.78	15.5	61	11
	0.67 S	0.95	14.8	56	11.6
	1.19 N	1.12	11.8	60	11.7
	1.55 N	1.32	13.1	64	10.8
	2.25 SN	1.92	11	64	10.3
Healthy 3	0.78 I	0.66	11.9	78	8.4
	0.89 N	0.77	13	68	10.8
	1.27 T	1	13.8	63	10.7
	1.67 T	1.16	10.7	63	11
	1.75 IT	1.23	11.2	57	12.3
		Average	12.1	62.6	10.9
		SD	1.8	7.9	1.4
Patient 1	0.81 N	1.35	18.9	38	15
	1.26 T	1.45	15.2	51	10.3
	2.87 SN	2.74	22.4	33	13.8
Patient 2	0.48 ST	1.52	19.9	45	15.9
	0.67 S	1.75	19.6	41	14.7
Patient 3	2.30 N	2.01	17.5	40	14.6
	0.12 fovea	1.24	25.7	50	13.6
Patient 4	1.23 IT	1.44	18.6	58	11.9
	1.37 IT	1.44	20.7	42	15
		Average	19.8	44.2	13.9
		SD	3.0	7.6	1.8
			*P < 0.001	*P < 0.001	*P < 0.001

Contiguous sets of ∼100 cones were selected for analysis. The top three sets are from normal healthy eyes, and the lower four sets are from the four patients. SNIT refers to superior, nasal, inferior, and temporal retinal directions. In patients with peripherin/RDS mutations, the SD of the Voronoi domain area is greater, the percentage of six-sided polygons is lower, and the SD of the number of sides is greater. P values are listed on the lowest row of the table.