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. 2011 Feb 10;2(2):e120. doi: 10.1038/cddis.2011.2

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Copyright © 2011 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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In vivo genetic modulation of CDK5 rescues neurite outgrowth defects in the hippocampus of APP tg mice. Brain sections from 9-month-old wild-type control mice (non-tg), CDK5 heterozygous deficient (CDK5^+/−), APP tg mice, or crosses (CDK5^+/−/APP) were processed for immunohistochemical analysis with an antibody against doublecortin (DCX) and developed with DAB. All images are from the dentate gyrus of the hippocampus. (a–d) Immunohistochemical analysis of DCX-immunoreactive cells in the dentate gyrus of non-tg, CDK5^+/−, APP tg mice, or CDK5^+/−/APP crosses. Brackets denote representative DCX-immunoreactive processes extending from cells in the SGZ that were measured. (e) Quantitative image analysis of the lengths of DCX-immunoreactive processes extending from DCX-immunoreactive cells located in the SGZ. ^*P<0.05 compared with wild-type controls by one-way ANOVA with post hoc Dunnett's test. ^#P<0.05 compared with APP tg mice by one-way ANOVA with post hoc Tukey–Kramer test. N=4 animals per group