Table 8.
Template | R | T. b. rhod. EC50 (µM) |
L6 Cytotox EC50 (µM) |
Selectivity Index |
---|---|---|---|---|
A | 2,4-Cl2 | 0.065 | 0.49 | 31 |
A | 2-Br, 4-F | 0.08 | 1.1 | 14 |
A | H | 0.05 | 1.0 | 20 |
B | 2,4-Cl2 | 0.29 | 5.2 | 18 |
B | 2,4- (CH3)2 |
0.22 | 5.3 | 24 |
B | 2,4-Br2 | 0.51 | 29 | 74 |