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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Curr Top Med Chem. 2011;11(10):1255–1274. doi: 10.2174/156802611795429167

Table 8.

Anti-trypanosomal 2-aryloxy-1,4-anthraquinones and 1,4-napthoquinones.

graphic file with name nihms293647t12.jpg
Template R T. b. rhod.
EC50 (µM)
L6 Cytotox
EC50 (µM)
Selectivity
Index
A 2,4-Cl2 0.065 0.49 31
A 2-Br, 4-F 0.08 1.1 14
A H 0.05 1.0 20
B 2,4-Cl2 0.29 5.2 18
B 2,4-
(CH3)2
0.22 5.3 24
B 2,4-Br2 0.51 29 74