TABLE 1.
In vitro activities of BB-83698 and comparator agents against susceptible and resistant S. pneumoniae strains
| Resistance mechanism or phenotype | Strain | BB-83698 MIC/ MBC (μg/ml) | MIC (μg/ml)a
|
||
|---|---|---|---|---|---|
| ERY | CIP | PEN | |||
| Wild type | P-4241 | 0.06/0.125 | 0.06 | 1 | 0.032 |
| Macrolide resistant | P-6254 | 0.125/0.125 | 1,024 | 0.016 | |
| ParC and GyrA | C42-Sp6 | 0.125/0.125 | 32 | ||
| Quinolone efflux | N42-6R1 | 0.125/0.25 | 4 | ||
| Penicillin resistant | P-12698 | 0.125/0.25 | 0.06 | 4 | |
| Multiresistant | P-15986 | 0.125/0.125 | >256 | 8 | |
a
ERY, erythromycin; CIP, ciprofloxacin; PEN, penicillin.