Fig. 8.

Human (a, b, e, f) cases of central centrifugal cicatricial alopecia compared to mouse B6 alopecia and dermatitis (c, d,g, h). Premature desquamation of the inner root sheath (arrow) is noted in some follicles on vertical (b) and horizontal (f) sections. Such follicles are prone to marked thinning of the outer root sheaths with reactive perifollicular inflammation (b, f) and eventually entry of the hair fiber into the dermis with resulting destructive chronic granulomatous inflammation (f). Changes are similar if not identical in mouse skin (c, d, g, h).