TABLE 1.
MICs to FLZ and viabilities of C. albicans strains in YNB plus acetic acid plus FLZ
| Strain | MIC (μg/ml)c | Viability ratiod |
|---|---|---|
| ATCC 32354a | 0.5 | <0.0005 |
| 116b | 0.5 | <0.0005 |
| 28P | 0.5 | <0.0005 |
| 132 | >64 | <0.0005 |
| 368 | >64 | <0.0005 |
| 370 | >64 | <0.0005 |
| 372 | >64 | <0.0005 |
| 453 | >64 | 4 |
| 943 | >64 | <0.0005 |
a
Standard laboratory strain (B311).
b
Isolate from a patient with recurrent vulvovaginal candidiasis. All others are clinical isolates from our repository.
c
Determined by standard NCCLS method (45, 46).
d
Ratio of viable cells on day 6 to initial inoculum. Initial inoculum of 2 × 104 cells/ml cells/ml into YNB plus 20 mM acetic acid, 64 μg of FLZ/ml and pH adjusted to 4.2. Since the viability assay cannot detect less than 10 cells/ml, 0 colonies is formally a ratio of <0.0005. Controls without FLZ grew to turbidity (data not shown).