TABLE 2.
Antimicrobial activities of synthetic polypeptides mimicking fungal poly(arginyl-histidine)a
| Polypeptide | Structure | MIC (μg/ml)
|
|
|---|---|---|---|
| B. subtilis | E. coli | ||
| (RH)1 | NH2-RH-COOH | >500 | >500 |
| (RH)2 | NH2-RHRH-COOH | >500 | >500 |
| (RH)3 | NH2-RHRHRH-COOH | 100 | 100 |
| (RH)4 | NH2-RHRHRHRH-COOH | 10 | 10 |
| (RH)5 | NH2-RHRHRHRHRH-COOH | 10 | 10 |
| (RH)6 | NH2-RHRHRHRHRHRH-COOH | 10 | 10 |
| (HR)5 | NH2-HRHRHRHRHR-COOH | 10 | 10 |
| (KH)5 | NH2-KHKHKHKHKH-COOH | 10 | 10 |
| (RG)5 | NH2-RGRGRGRGRG-COOH | 100 | 100 |
| (GH)5 | NH2-GHGHGHGHGH-COOH | >500 | >500 |
| (RC)5 | NH2-RCRCRCRCRC-COOH | 10 | 20 |
a
The test bacteria were B. subtilis IFO3336 and E. coli IFO3301; the medium was nutrient broth.