TABLE 1.
Mean pharmacokinetic parameters of FLC, ITC, and GRF concentrations in plasma and abdominal skin following a single oral dose to guinea pigs (n = 4 to 6)
| Drug | Dose (mg/kg) | Results
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stratum corneum
|
Epidermis-cutis
|
Subcutaneous fatty tissue
|
Plasma
|
|||||||||
| Cmax (μg/g) | AUC72 (μg · h/g) | Cmax (μg/g) | AUC (μg · h/g) | t1/2 (h) | Cmax (μg/g) | AUC (μg · h/g) | t1/2 (h) | Cmax (μg/ml) | AUC (μg · h/ml) | t1/2 (h) | ||
| FLC | 10 | 18.1 | 1,026 | 8.3 | 89.7 | 6.4 | 3.1 | 28.9 | 4.9 | 11.5 | 12.0 | 6.3 |
| ITC | 20 | 31.6 | 949 | 1.93 | 45.6 | 11.6 | 42.0 | 1,067 | 10.4 | 0.70 | 12.4 | 13.9 |
| GRF | 25 | 15.8 | 307 | 3.65 | 37.9 | 5.9 | 11.3 | 106 | 5.5 | 2.34 | 25.5 | 6.5 |