Figure 5.

Histology of UroIICRE⁺ β-catenin^exon3/exon3p21^−/−mouse. H&E reveals bladder tumour (a) with upregulation of Ki67, β-catenin and pERK1/2 (b–d). There is minimal upregulation of p53 and p21 (e and f). Black bar measures 200 μm (20 × magnification). Kaplan–Meier curves of tumour-free survival of UroIICRE⁺p21^−/− and UroIICRE⁺β-catenin^exon3/exon3p21^−/− cohorts (g). p21 (UroIICRE⁺p21^−/−) and Bcatenin p21 (UroIICRE⁺β-catenin^exon3/exon3p21^−/−)