Table 1.

Baseline Spontaneous Epileptiform Activity Assessed by EEG Analysis in Chronic Epileptic Mice used for Pharmacological Experiments

Mouse I.D.	Time in Epileptic Activity (min)
	Days
	1	2	3	1	2	3
	9:00–11:00 AM			4:00–6:00 PM
1	44.2	38.9	25.0	33.2	35.7	35.6
2	32.1	32.4	34.6	39.7	36.8	35.3
3	38.7	41.0	32.1	29.3	36.1	37.3
4	19.8	11.6	14.5	19.5	10.8	14.8
5	33.0	37.5	33.4	38.1	32.1	38.0
6	42.2	30.2	34.1	27.0	32.1	26.0
7	38.2	32.3	35.3	51.1	34.2	33.2
8	66.0	66.3	60.2	63.2	60.3	63.1
9	11.1	12.3	14.0	17.2	13.2	12.4
10	35.1	30.8	31.3	29.4	33.6	31.0
11	35.0	30.8	31.2	28.9	30.2	29.5
12	40.8	36.8	33.0	32.1	31.4	28.5
13	15.0	18.4	14.3	22.1	20.9	16.4
14	25.6	20.1	18.1	23.1	29.4	28.6
15	39.5	36.3	36.1	30.2	35.0	28.4
16	36.8	40.4	33.2	32.0	31.3	30.4
17	30.7	25.3	25.1	26.0	18.9	26.1
18	25.1	29.6	27.9	24.9	32.7	31.4
19	27.0	30.9	29.7	28.9	29.7	27.9
20	28.8	26.2	29.5	28.6	25.6	26.6
21	43.1	37.8	40.1	42.7	39.6	44.5

Mice were used as follows: numbers 1 to 9 were injected with 200 mg/kg VX-765; numbers 10 to 15 were injected with 50 mg/kg VX-765; numbers 16 to 21 were injected with 12.5 mg/kg VX-765. Mice numbers 5 to 9 were also treated with 50 mg/kg phenytoin before VX-765; mice numbers 10 to 15 were also treated with 3 mg/kg dexamethasone after treatment with 50 mg/kg VX-765. (“For details on treatment protocols see Methods and FIG. 3.”).

EEG = electroencephalographic; I.D. = identification.