Table 2.
Dose-Response Effect of VX-765 on Acute Seizures
| Dose (mg/kg) | Onset time (minutes) | Number of seizures | Time in seizures (minutes) | |
|---|---|---|---|---|
| Vehicle | — | 8.4 ± 0.9 | 14.0 ± 1.0 | 12.0 ± 1.0 |
| VX-765 | 12.5 | 6.7 ± 0.7 | 13.0 ± 3.0 | 8.8 ± 1.7 |
| 50.0 | 10.2 ± 1.5 | 8.0 ± 1.0* | 6.4 ± 1.4† | |
| 100.0 | 18.1 ± 2.2† | 6.0 ± 1.0† | 5.0 ± 1.4† | |
| 200.0 | 19.8 ± 4.1† | 6.0 ± 1.0† | 3.7 ± 0.8† |
VX-765 (12.5, 50, 100, 200 mg/kg) was injected intraperitoneally once a day for 3 consecutive days; on day 4, the drug was injected 45 minutes before kainic acid. Kainate (7 ng in 0.5 μl) was injected unilaterally in the left hippocampus in freely moving C57BL6 mice (n = 7–-12).
IL = interleukin.
*p < 0.05; †p < 0.01 versus vehicle-injected mice by one-way analysis of variance followed by Tukey’s post hoc test.