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Comparison between the rSERCA1a, hSPCA1, and hSPCA2 structures. Homology models of hSPCA1 (B) and hSPCA2 (C) based on the E2 rSERCA1a structure (A) (1WPG) (Toyoshima et al. 2004). Homology models were obtained from the SWISS-MODEL repository (Kiefer et al. 2009). SPCA1 and SPCA2 are very similar, but in general more compact than SERCA1a. The longer loops in SERCA are indicated in red and are predominantly found in the N-domain and in the luminal loops.
