Figure 2.

Differential effects of different matrices on fibroblast spreading and FA formation. This figure shows morphological and molecular differences between integrin adhesions formed in response to adhesion to different ECM matrices. Vinculin (Vin)-labeled adhesions (green) are shown following adhesion of fibroblasts to fibronectin (FN) via the α5β1 integrin, or to vitronectin (VN) via the αvβ3 integrin. Notice that VN induces less cell spreading compared to cells adhering to FN, and that the distribution of FAs is largely peripheral. Original images for this panel were provided by Baruch Zimerman.