Scaffolding interactions of the integrin adhesome network (see http://www.adhesome.org). Adhesome components include membrane receptors (dark green rectangles), adaptor proteins (purple rectangles), actin-associated proteins (magenta ovals), tyrosine kinases (red diamonds) and phosphatases (blue diamonds), serine/threonine kinases (red elongated hexagons) and phosphatases (blue elongated hexagons), G-proteins (orange ovals), GEFs (yellow diamonds), and GAPs (yellow elongated octagons). This diagram was prepared by Ronen Zaidel-Bar, based on Zaidel-Bar et al. 2007a; Zaidel-Bar and Geiger 2010.