Table 1.

Select proteins showing Golgi phenotypes following knockdown.

Proteins	Localization	Golgi knockdown phenotype	Cytoskeletal interactions	Suggested functions	References for Phenotype
Lava lamp	Drosophila Golgi	Immotile (no apical movement)	Dynein, dynactin, Clip190, α-spectrin	Motor adaptor	Papalous et al. 2004
Golgin-160	cis-Golgi	Immotile dispersed stacks	Unknown	Cargo receptor, motor adaptor?	Yadav et al. 2009
GMAP210	cis-Golgi	Immotile dispersed stacks	Microtubules, Rab2	Tether	Rios et al. 2004
Golgin-245	trans-Golgi	Immotile dispersed stacks	Unknown (dynein not detected)	Tether, endosome-TGN traffic	Yoshino et al. 2005
Dynein	Endomembranes	Immotile dispersed stacks	Dynactin, microtubules	Motor	Harada et al. 1998,Palmer et al. 2009
Dynactin	Centrosome, +tips	Immotile dispersed stacks	Dynein, microtubules	Motor adaptor/ activator	King and Schroer 2000
Huntingtin	trans-Golgi, endosomes	Dispersed stacks (partial)	Dynein, microtubules	Motor adaptor (endosome)	Caviston et al. 2007
BICD1/2	trans-Golgi network	Dispersed stacks (mild)	Dynein, Rab6	Motor adaptor, Golgi-ER traffic	Fumoto et al. 2006
Golgin-97	trans-Golgi	Dispersed stacks	Unknown	Tether, endosome-TGN traffic	Lu et al. 2004
Golgin-84	trans-Golgi	Dispersed stacks	Unknown	Tether, intra-Golgi retrograde traffic	Diao et al. 2003
GCC185	trans-Golgi	Dispersed stacks	CLASP1/2	Microtubule anchor, tether	Derby et al. 2007
MyosinVI	Golgi	Dispersed stacks	Optineurin	Motor	Warner et al. 2003
Optineurin	Golgi	Dispersed stacks	MysoinVI	Motor adaptor	Sahlender et al. 2005
ZW-10	ER, Golgi	Dispersed stacks	Dynein, dynactin	Tether, motor adaptor at kinetochore	Hirose et al. 2004
Rab2	cis-Golgi, ERGIC	Dispersed stacks	Dynein, microtubules	GTPase, ER-to-Golgi	Tisdale et al. 1999
Rab18	cis-Golgi	Dispersed stacks	Unknown	GTPase, ER-to-Golgi	Dejgaard et al. 2008
Rab43	cis-Golgi	Dispersed stacks	Unknown	GTPase, ER-to-Golgi	Dejgaard et al. 2008
Rab6	trans-Golgi	Dispersed stacks	Dynein	GTPase, Golgi-to-ER	Young et al. 2005
Hook3	Centrosome	Dispersed stacks (on overexpression)	PCM1	Centrosome anchor	Walenta et al. 2001
CLASP1/2	Golgi, +tips	Unlinked clustered stacks	CLIP, EB1, +tip proteins	Microtubule anchor (Golgi) & regulator	Mimori Kiyosue et al. 2005
GRASP55	Medial Golgi	Unlinked clustered stacks	Unknown	Stacking, linking, cargo receptor	Feinstein and Linstedt 2007
GRASP65	cis-Golgi	Unlinked clustered stacks	Unknown	Stacking, linking, cargo receptor	Puthenveedu et al. 2006
GM130	cis-Golgi	Unlinked clustered stacks	Unknown	Stacking, linking, cargo receptor, scaffold	Puthenveedu et al. 2006
Golgin-45	Medial Golgi	Unlinked clustered stacks	Unknown	Stacking, linking, cargo receptor, scaffold	Short et al. 2001
p115	ERGIC, cis-Golgi	Dispersed vesiculated Golgi	Unknown	Tether	Puthenveedu and Linstedt 2004
Rab1	ERGIC	Dispersed vesiculated Golgi	Unknown	GTPase, ER-to-Golgi	Wilson et al. 1994
Spectrin	Endomembranes	Unknown	Arp1	Scaffold, motor adaptor	Holleran et al. 2001

Proteins are grouped according to phenotype. Listed interactions are only those most closely related to the cytoskeleton and motility. Possible functions are noted but most are beyond the scope of this review and not discussed. Citations are restricted to those initially describing the knockdown phenotypes.