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Detoxification of Aβ aggregates by DAF-16 and HSF-1. The Aβ is produced throughout life by proteolysis of the amyloid precursor protein. In youthful animals, Aβ aggregates are believed to be detoxified by an active aggregation activity, regulated by the transcription factor DAF-16, and a disaggregation/proteolytic degradation pathway downstream of the transcription factor HSF-1.
