TABLE 1.

Concentrations of clarithromycin and amikacin in sera of rabbits in groups B to F with induced pyelonephritis caused by multidrug-resistant P. aeruginosa

Time (h) of follow-up	Mean ± SE concn (μg/ml) of the indicated drug
	Group B, clarithromycin	Group C, clarithromycin	Group D, amikacin	Group E		Group F
				Clarithromycin	Amikacin	Clarithromycin	Amikacin
1	9.90 ± 1.28	13.00 ± 1.43	12.99 ± 4.07	7.33 ± 1.41	13.78 ± 4.71	10.50 ± 1.46	22.60 ± 4.22
2	7.13 ± 0.48	6.46 ± 0.63	13.45 ± 1.62	5.42 ± 0.78	13.90 ± 4.15	7.28 ± 0.47	17.69 ± 5.87
3	4.90 ± 0.50	15.38 ± 0.38	—a	—	—	13.50 ± 0.50	8.50 ± 1.50
24	1.05 ± 0.05	NDb	ND	ND	ND	ND	ND

^a—, no sampling was performed.

^bND, not detectable.