Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Comparison of canine and murine haemophilia.
| Mice | Dogs | |
|---|---|---|
| Factor antigen and activity | Absent | Absent |
| cDNAs for FVIII and FIX available | Yes | Yes |
| Genetic background | Outbred and inbred | Outbred |
| Introduce other mutations | Feasible | Difficult |
| Large amounts of plasma | Difficult | Yes |
| Life expectancy | ~2 years | >10 years |
| Preclinical predictive accuracy | Limited data | Yes (>50 years’ data) |
| Spontaneous bleeds | Rare | Frequent |
FVIII, factor VIII; FIX, factor IX.
